➕ The national network of Research Centers in Human Nutrition (CRNH) is made up of 4 components:
➰ Its objective lies in the desire to coordinate and develop research efforts in nutrition on the national territory, providing pooled capacities ranging from the study of the molecule to clinical and epidemiological research.
➰ The CRNH network is governed by a management board (Director and co-Director), a board of directors and a scientific council. It is based on multiple institutional partnerships (INRA, INSERM) and academic (Universities, CHU), as well as industrial support.
➕ Each CRNH has one or more associated platforms for carrying out analyses in human nutrition, and more specialized themes developed according to the scientific expertise of each center:
▶️ CRNH Auvergne:
✒️ Created in 1992 under the supervision of the Clermont-Ferrand University Hospital, INRAe, the University of Clermont Auvergne, the Jean Perrin Center and INSERM
✒️Direction: Professor Ruddy RICHARD / Contact form
✒️Scientific themes: Preventive human nutrition in healthy and elderly people / Mechanisms of protein muscle wasting in aging / Pathophysiological alterations of the locomotor system (bone or muscle tissue-sarcopenia) / Cardio-metabolic diseases / Pathologies associated with the gastrointestinal tract / Hormone-dependent cancers
8 research units with 11 associated teams:
- UNH (UCA & INRAe) Human Nutrition Unit
- M2iSH (UCA & INSERM) Microbes, Intestine, Inflammation and Host Susceptibility
- Medis (UCA & INRAe) Microbiology, Digestive Environment and Health AME2P
- Laboratory (UCA Team) Laboratories of Metabolic Adaptations to Exercise in Physiological and Pathological conditions
- NEURO-DOL Unit (UCA & Inserm): fundamental and clinical pharmacology of pain
- GReD Unit Genetics Reproduction and Development (joint unit Inserm & UCA & CNRS): lipids and nuclear receptors
- IMoST Unit (UCA & Inserm & CJP): “molecular imaging and theranostic strategies”
- Physics laboratory (CNRS & UCA): Repair of the mitochondrial genome
✒️Associated platform: Nutrition Exploration Unit (UEN)
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▶️ CRNH Ile de France:
✒️Organization: Associated Units and Teams (outpatient clinical analyses):
- Site Pitié Salpétrière :
- Site Avicenne et les sites de l’unité CRESS :
- Site Paris, Saint-Pères
- Sites AgroParisTech/INRAE (Claude Bernard, Massy, Jouy) :
- The UMR914 INRAE, AgroParisTech, Université Paris-Saclay, Physiology of Nutrition and Eating Behavior (PNCA) (Claire Gaudichon, Juliane Calvez)
- The INRAE unit, AgroParisTech, Université Paris-Saclay, Paris-Saclay Food and Bioproduct Engineering (SayFood) (Catherine Bonazzi, Anne Saint-Eve)
- The UMR INRAE, AgroParisTech, Université Paris-Saclay, MICALIS (Stéphane Aymerich, Philippe Langella)
- The UR INRAE, MétaGénoPolis (Alexandre Cavezza, Joël Doré)
✒️Created in 2003 under the supervision of AP-HP, Inserm, INRA, CNAM, Université Paris 6 and Paris 13 and INAPG
✒️Direction: Pr Karine Clément
✒️Members: Jean Michel Oppert, Karine Clément, Philippe Ravaud, Mathilde Touvier, Mélanie Deschasaux, Marie-Aline Charles, Blandine de Lauzon- Guillain, Robert Benamouzig, Georges Areini, Robert Barouki, Xavier Coumoul, Robert Barouki, Sylvie Bortoli, Minji Kim, Xavier Coumoul, Claire Gaudichon, Benjamin Alles, Juliane Calvez, Catherine Bonazzi, Anne Saint-Eve, Stéphane Aymerich, Philippe Langella, Alexandre Cavezza, Joël Doré
✒️Scientific themes:
➰ Analysis of eating behavior and consumption through measurements of the evolution of behaviors, regional variations, specific populations (children, seniors, social categories, patients), and the design of nutritional typologies.
➰ Study of the determinants of behavior and nutritional status, from different economic social angles (learning of taste, social acceptability of foods, lifestyle, life cycles, …), sensory genetics (role of genetic variants and relationship with clinical phenotypes related to behavior and their temporal evolution), psycho-physiological (signals and mechanisms controlling the orientation and/or cessation of food intake, nycthemeral periodicity) and physio-pathological (effects and consequences of physical activity, changes in dietary modes on bioclinical and tissue phenotypes, predictability of responses)
➰ Study of the relationships between behavior and health, integrating the exposome and environmental pollution, quality of life, morbidity and mortality, physiological functions, risk factors for chronic diseases, interactions between eating behavior, genetic and microbial factors and risk factors
➰ Study of the capacity of protein sources to meet the nutritional needs of the healthy or fragile human, by evaluations of digestive kinetics and efficiencies, metabolic bioavailability and associated metabolic responses, in healthy subjects or suffering from digestive pathologies
➰ Study of the pathophysiology of the relationships between environmental changes, behaviors and human health through the study of the microbiota and microbial metabolism, particularly through clinical investigation
➰ Evaluation of prevention strategies, communication and nutritional education, targeting the impact of prevention strategies on behavior and on food supply, social marketing, …) and Research with direct impact to guide public policies of nutrition and public health
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▶️ CRNH Ouest:
✒️ Created in 1995 under the auspices of the Ministry of Research at the initiative of INRAE, INSERM, CHU Nantes and Nantes University (renewed on 04/05/2022 for 5 years)
✒️ Public Interest Group (GIP) bringing together 15 Research Units and University Hospital Services including:
- EA 2160 - ICO NANTES,
- Inra-UR1 EQUIPE ALICE,
- Laboratory Biochemistry Human Nutrition - AGROCAMPUS West,
- TENS - UMR INSERM U1235,
- BAI ONIRIS NANTES,
- INRA STLO RENNES,
- U1280 PhAN, INSERM U1063 ANGERS,
- CHU Allergology Unit ANGERS,
- LABERCA, U1069 TOURS,
- UR 1268 BIA,
- NP3 Nutrition, pathophysiology and pharmacology unit,
- INSERM U1087 Team III,
- INSERM U1087 Team IV,
- INSERM U1087 Team V,
- NUMECAN INSERM 1241
✒️ Direction:
- Clair-Yves BOQUIEN (Director)
- Samy HADJADJ (Deputy Director)
- David JACOBI (Deputy Director)
✒️ Members of the GIS CRNH Ouest:
✒️Research Axes:
✒️Associated platform:
M.shark platform: Mass Spectrometry for Health, Analytical REsearch and Kinetics attached to the UMS BioCORE and the CORSAIRE platform of Biogenouest
✒️Interactions:
✒️Contact:
crnh-ouest@univ-nantes.fr
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▶️ CRNH Rhône-Alpes:
✒️ The CRNH Rhône-Alpes is a Public Interest Group created in 1996 bringing together INSERM, the Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 'Université Grenoble-Alpes and CHU Grenoble-Alpes, Université Jean Monnet and CHU de St-Etienne.
✒️ The management team of the CRNH Rhône-Alpes can rely on 3 distinct poles: the Clinical Exploration Center, the Mass Spectrometry Analysis Center and the administrative pole.
✒️Governance: Julie-Anne Nazare
✒️Scientific themes:
- Nutritional adaptations: metabolic stress and environment
- Mechanisms of development of nutritional diseases
- Muscle mass, physical inactivity and sedentary lifestyle
- Modulation of the nutritional quality of food
- Cardioprotection and cardio metabolic risk
✒️Associated platforms:
